Presenting itself as a high-profile weight-loss drug, Ozempic (semaglutide) was first marketed for the treatment of type 2 diabetes. Though it does help some patients, its associated benefits and risks require consideration.
How Ozempic Causes Weight Loss
The medication acts through the following mechanisms:
Imitates GLP-1 hormones that promote appetite regulation.
Delays gastric emptying (increases sense of fullness).
Does its action on brain receptors to reduce craving.
Clinical trials show an average weight loss of 15-20% over 68 weeks in concert with lifestyle changes.
Pros and Cons
Documented Advantages:
- FA-approved for chronic weight management (as Wegovy)
- May improve blood sugar levels in diabetics
- Cardiovascular benefit is seen in recent trials
Reported Concerns:
Gastrointestinal side effects, e.g., nausea and diarrhea, are common.
Possible increased risk of thyroid tumors (animal studies).
Costs between 900-1,300 dollars per month without insurance.
Weight regain after stopping (studies show around 66% regain).
Alternative Approaches
For some, this may mean things not requiring the use of a pill:
Lifestyle Modification Programs – CDC-recognized diets/exercise plans show 5-10% sustained weight loss.
Behavioral Therapy – Getting to the emotional weighting.
Phentermine-topiramate induces weight loss with similar effect only at a lower monetary cost.
Bariatric surgery remains the best long-term solution for severe obesity (25% – 30% weigh loss sustained).
Things to Consider
Patients should:
Go for obesity medicine specialists for personalized plans
Understand that medication is not a solitary solution
Monitor for rare but very serious side effects (pancreatitis, gallbladder problems)
Complement treatment with nutritional counseling.
Ozempic is a very profound drug, but it is effective when partnered with other paradigms of weight management worthy of consideration. This is not just about temporarily suppressing appetite by medication; real and lasting solutions need to focus on the root causes of weight gain. Different people respond differently, so it is paramount that they get professional guidance along the way to ensure a safe and effective treatment.